Drug interactions
Sirolimus + Tenofovir disoproxil
Severity: Moderate
Sirolimus and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can adversely affect renal function. Sirolimus can cause proteinuria and may worsen renal injury, particularly when combined with other nephrotoxins, and reduced renal function may increase tenofovir exposure.
What this interaction means in plain words
Sirolimus and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity with secondary reduced tenofovir clearance.
What to do
Monitor serum creatinine, phosphate and urine protein regularly. Reduce tenofovir dosing frequency per creatinine clearance or choose an alternative if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Sirolimus and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can adversely affect renal function. Sirolimus can cause proteinuria and may worsen renal injury, particularly when combined with other nephrotoxins, and reduced renal function may increase tenofovir exposure.
How serious is the interaction between Sirolimus and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urine protein regularly. Reduce tenofovir dosing frequency per creatinine clearance or choose an alternative if renal function declines.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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