Drug interactions
Sirolimus + Triamcinolone acetonide injectable
Severity: Moderate
Sirolimus and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamcinolone is a corticosteroid that may weakly induce CYP3A4, which could lower sirolimus concentrations. Reduced sirolimus exposure may lessen immunosuppression and raise the risk of rejection. The effect is not well characterized and is likely modest with intermittent injections, and the additive immunosuppression of the two drugs also matters.
What this interaction means in plain words
Sirolimus and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 induction by the corticosteroid increasing sirolimus metabolism, plus additive immunosuppression.
What to do
Monitor sirolimus trough concentrations after starting or stopping repeated triamcinolone injections and adjust the sirolimus dose accordingly. Watch for signs of graft rejection or infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Sirolimus and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamcinolone is a corticosteroid that may weakly induce CYP3A4, which could lower sirolimus concentrations. Reduced sirolimus exposure may lessen immunosuppression and raise the risk of rejection. The effect is not well characterized and is likely modest with intermittent injections, and the additive immunosuppression of the two drugs also matters.
How serious is the interaction between Sirolimus and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations after starting or stopping repeated triamcinolone injections and adjust the sirolimus dose accordingly. Watch for signs of graft rejection or infection.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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