Drug interactions
Sirolimus + Turmeric
Severity: Minor
Sirolimus and Turmeric: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Turmeric (curcumin) may inhibit CYP3A4 and P-glycoprotein in vitro, which could raise sirolimus levels. Clinical evidence is limited, but sirolimus has a narrow therapeutic index.
What this interaction means in plain words
Sirolimus and Turmeric have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of intestinal and hepatic CYP3A4 and P-glycoprotein by curcuminoids.
What to do
Monitor sirolimus trough levels if turmeric supplements are used regularly in high doses. Keep supplement intake consistent.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Turmeric?
MediHelp rates the interaction as minor. Sirolimus and Turmeric have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Turmeric (curcumin) may inhibit CYP3A4 and P-glycoprotein in vitro, which could raise sirolimus levels. Clinical evidence is limited, but sirolimus has a narrow therapeutic index.
How serious is the interaction between Sirolimus and Turmeric?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels if turmeric supplements are used regularly in high doses. Keep supplement intake consistent.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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