Drug interactions
Sirolimus + Typhoid polysaccharide vaccine
Severity: Moderate
Sirolimus and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the antibody response to the inactivated typhoid polysaccharide vaccine, leaving incomplete protection. There is no added infection risk from the vaccine.
What this interaction means in plain words
Sirolimus and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus inhibits mTOR-dependent lymphocyte proliferation, reducing the immune response to vaccination.
What to do
Give the inactivated vaccine at least two weeks before travel where possible, and reinforce food and water precautions. Prefer it over the live oral vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Sirolimus and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the antibody response to the inactivated typhoid polysaccharide vaccine, leaving incomplete protection. There is no added infection risk from the vaccine.
How serious is the interaction between Sirolimus and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the inactivated vaccine at least two weeks before travel where possible, and reinforce food and water precautions. Prefer it over the live oral vaccine.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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