Drug interactions
Sirolimus + Typhoid vaccine live
Severity: Major
Sirolimus and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine may cause systemic Salmonella Typhi vaccine-strain infection in patients on sirolimus, and its efficacy may be reduced. Live vaccines are generally avoided during immunosuppression.
What this interaction means in plain words
Sirolimus and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Sirolimus impairs cell-mediated control of live attenuated bacteria and blunts vaccine response.
What to do
Avoid the live vaccine and use the inactivated injectable typhoid vaccine instead.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Typhoid vaccine live?
MediHelp rates the interaction as major. Sirolimus and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live oral typhoid vaccine may cause systemic Salmonella Typhi vaccine-strain infection in patients on sirolimus, and its efficacy may be reduced. Live vaccines are generally avoided during immunosuppression.
How serious is the interaction between Sirolimus and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine and use the inactivated injectable typhoid vaccine instead.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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