Drug interactions
Sirolimus + Yellow fever vaccine
Severity: Contraindicated
Sirolimus and Yellow fever vaccine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live yellow fever vaccine can cause serious viscerotropic or neurotropic disease in immunosuppressed patients, and the immune response may be inadequate. Sirolimus therapy is a recognised reason to avoid it.
What this interaction means in plain words
Sirolimus and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Sirolimus impairs lymphocyte-mediated control of live attenuated virus replication and blunts vaccine response.
What to do
Avoid the vaccine in patients on sirolimus; if travel to endemic areas is unavoidable, seek travel medicine advice and consider a medical exemption letter with mosquito-avoidance measures.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Sirolimus and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live yellow fever vaccine can cause serious viscerotropic or neurotropic disease in immunosuppressed patients, and the immune response may be inadequate. Sirolimus therapy is a recognised reason to avoid it.
How serious is the interaction between Sirolimus and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the vaccine in patients on sirolimus; if travel to endemic areas is unavoidable, seek travel medicine advice and consider a medical exemption letter with mosquito-avoidance measures.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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