Drug interactions
Sirolimus + Zoster vaccine recombinant
Severity: Moderate
Sirolimus and Zoster vaccine recombinant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from sirolimus may blunt the immune response to the recombinant zoster vaccine. The vaccine is non-live, so it can be given, but protection may be lower.
What this interaction means in plain words
Sirolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: immunosuppression reduces the antibody and T-cell response to vaccination.
What to do
Vaccinate when clinically appropriate, ideally before or at the lowest feasible level of immunosuppression. Do not delay vaccination unnecessarily in transplant patients, and follow up for breakthrough zoster.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Sirolimus with Zoster vaccine recombinant?
MediHelp rates the interaction as moderate. Sirolimus and Zoster vaccine recombinant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from sirolimus may blunt the immune response to the recombinant zoster vaccine. The vaccine is non-live, so it can be given, but protection may be lower.
How serious is the interaction between Sirolimus and Zoster vaccine recombinant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate when clinically appropriate, ideally before or at the lowest feasible level of immunosuppression. Do not delay vaccination unnecessarily in transplant patients, and follow up for breakthrough zoster.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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