Drug interactions
Sitagliptin + Triamcinolone
Severity: Moderate
Sitagliptin and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids increase blood glucose and can reduce the glycemic control achieved with sitagliptin. Hyperglycemia is most likely after systemic exposure or repeated depot injections.
What this interaction means in plain words
Sitagliptin and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sitagliptin belongs to Endocrine; Triamcinolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through corticosteroid-induced insulin resistance and increased hepatic glucose production.
What to do
Monitor blood glucose closely after triamcinolone is given and adjust antidiabetic therapy if needed. Reduce doses again when the corticosteroid effect wears off.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Sitagliptin with Triamcinolone?
MediHelp rates the interaction as moderate. Sitagliptin and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids increase blood glucose and can reduce the glycemic control achieved with sitagliptin. Hyperglycemia is most likely after systemic exposure or repeated depot injections.
How serious is the interaction between Sitagliptin and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after triamcinolone is given and adjust antidiabetic therapy if needed. Reduce doses again when the corticosteroid effect wears off.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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