Drug interactions
Smoking + Tizanidine
Severity: Moderate
Smoking and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Smoking induces CYP1A2, the main enzyme clearing tizanidine. Smokers may have lower tizanidine concentrations and a weaker effect. Stopping smoking can raise levels and increase adverse effects.
What this interaction means in plain words
Smoking and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Polycyclic aromatic hydrocarbons in smoke induce CYP1A2, increasing tizanidine clearance.
What to do
Titrate tizanidine to clinical response in smokers. If the patient stops smoking, monitor for hypotension and sedation and consider a dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Smoking with Tizanidine?
MediHelp rates the interaction as moderate. Smoking and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Smoking induces CYP1A2, the main enzyme clearing tizanidine. Smokers may have lower tizanidine concentrations and a weaker effect. Stopping smoking can raise levels and increase adverse effects.
How serious is the interaction between Smoking and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate tizanidine to clinical response in smokers. If the patient stops smoking, monitor for hypotension and sedation and consider a dose reduction.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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