Drug interactions
Sofosbuvir-velpatasvir + Topotecan
Severity: Moderate
Sofosbuvir-velpatasvir and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and may increase systemic exposure to oral topotecan, a BCRP substrate. This could raise myelosuppression and other toxicities.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sofosbuvir-velpatasvir belongs to Anti Virals; Topotecan belongs to Oncology.
Why it happens
Velpatasvir inhibits BCRP efflux transport, increasing topotecan absorption and reducing clearance.
What to do
Monitor complete blood counts closely during coadministration, particularly with oral topotecan. Consider delaying HCV treatment until chemotherapy is finished if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Topotecan?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits BCRP and may increase systemic exposure to oral topotecan, a BCRP substrate. This could raise myelosuppression and other toxicities.
How serious is the interaction between Sofosbuvir-velpatasvir and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during coadministration, particularly with oral topotecan. Consider delaying HCV treatment until chemotherapy is finished if feasible.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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