Drug interactions
Sofosbuvir / velpatasvir + Voriconazole
Severity: Minor
Sofosbuvir / velpatasvir and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may modestly increase velpatasvir exposure because velpatasvir is partly metabolized by CYP3A4. The effect is generally small and sofosbuvir/velpatasvir has a wide tolerability margin.
What this interaction means in plain words
Sofosbuvir / velpatasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4, a minor elimination pathway for velpatasvir.
What to do
No dose change is usually needed; monitor for adverse effects such as headache and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Sofosbuvir / velpatasvir with Voriconazole?
MediHelp rates the interaction as minor. Sofosbuvir / velpatasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may modestly increase velpatasvir exposure because velpatasvir is partly metabolized by CYP3A4. The effect is generally small and sofosbuvir/velpatasvir has a wide tolerability margin.
How serious is the interaction between Sofosbuvir / velpatasvir and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for adverse effects such as headache and nausea.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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