Drug interactions
Sofosbuvir-velpatasvir + Voxelotor
Severity: Minor
Sofosbuvir-velpatasvir and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor is a moderate CYP3A4 inhibitor in vitro and may raise exposure to CYP3A4 substrates. Velpatasvir is partly metabolized by CYP3A4, so a modest increase is possible. This is unlikely to be clinically important for a drug with a wide therapeutic margin.
What this interaction means in plain words
Sofosbuvir-velpatasvir and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sofosbuvir-velpatasvir belongs to Anti Virals; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, which may modestly reduce velpatasvir clearance.
What to do
No dose adjustment is generally needed; monitor for HCV regimen adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Sofosbuvir-velpatasvir with Voxelotor?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor is a moderate CYP3A4 inhibitor in vitro and may raise exposure to CYP3A4 substrates. Velpatasvir is partly metabolized by CYP3A4, so a modest increase is possible. This is unlikely to be clinically important for a drug with a wide therapeutic margin.
How serious is the interaction between Sofosbuvir-velpatasvir and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for HCV regimen adverse effects such as headache and fatigue.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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