Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Sulbactam / durlobactam
Severity: Minor
Sofosbuvir-velpatasvir-voxilaprevir and Sulbactam / durlobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulbactam is partly cleared by renal organic anion transporters, and inhibition could raise its concentrations. The clinical significance with voxilaprevir is unclear, and beta-lactams generally have a wide safety margin.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of renal tubular OAT-mediated secretion of sulbactam; this is predicted rather than demonstrated.
What to do
No routine dose change is needed. Monitor for beta-lactam adverse effects such as rash or diarrhea during the short treatment course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Sulbactam / durlobactam?
MediHelp rates the interaction as minor. Sofosbuvir-velpatasvir-voxilaprevir and Sulbactam / durlobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulbactam is partly cleared by renal organic anion transporters, and inhibition could raise its concentrations. The clinical significance with voxilaprevir is unclear, and beta-lactams generally have a wide safety margin.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Sulbactam / durlobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for beta-lactam adverse effects such as rash or diarrhea during the short treatment course.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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