Drug interactions
Sofosbuvir-velpatasvir-voxilaprevir + Tenofovir df
Severity: Moderate
Sofosbuvir-velpatasvir-voxilaprevir and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir and voxilaprevir inhibit P-glycoprotein and increase tenofovir exposure when tenofovir DF is given with this regimen. Higher tenofovir levels raise the risk of renal toxicity and bone effects, especially in patients with renal impairment or other nephrotoxic risk factors.
What this interaction means in plain words
Sofosbuvir-velpatasvir-voxilaprevir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition by velpatasvir and voxilaprevir increases intestinal absorption of tenofovir DF.
What to do
Monitor renal function, including creatinine clearance, urine glucose and urine protein, during coadministration. Avoid other nephrotoxic drugs and consider tenofovir alafenamide in patients at renal risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Sofosbuvir-velpatasvir-voxilaprevir with Tenofovir df?
MediHelp rates the interaction as moderate. Sofosbuvir-velpatasvir-voxilaprevir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir and voxilaprevir inhibit P-glycoprotein and increase tenofovir exposure when tenofovir DF is given with this regimen. Higher tenofovir levels raise the risk of renal toxicity and bone effects, especially in patients with renal impairment or other nephrotoxic risk factors.
How serious is the interaction between Sofosbuvir-velpatasvir-voxilaprevir and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, including creatinine clearance, urine glucose and urine protein, during coadministration. Avoid other nephrotoxic drugs and consider tenofovir alafenamide in patients at renal risk.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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