Drug interactions
Solifenacin + St john's wort
Severity: Moderate
Solifenacin and St john's wort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
St John's wort induces CYP3A4 and can lower solifenacin concentrations. This may reduce control of overactive bladder symptoms.
What this interaction means in plain words
Solifenacin and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases solifenacin clearance.
What to do
Advise against St John's wort or monitor for reduced efficacy. Re-evaluate the dose if the herbal product is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with St john's wort?
MediHelp rates the interaction as moderate. Solifenacin and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. St John's wort induces CYP3A4 and can lower solifenacin concentrations. This may reduce control of overactive bladder symptoms.
How serious is the interaction between Solifenacin and St john's wort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against St John's wort or monitor for reduced efficacy. Re-evaluate the dose if the herbal product is stopped.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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