Drug interactions
Solifenacin + Trifluoperazine
Severity: Moderate
Solifenacin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has some anticholinergic activity, so combining it with solifenacin adds to dry mouth, constipation, urinary retention and confusion. Both agents can prolong the QT interval.
What this interaction means in plain words
Solifenacin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and additive QT prolongation.
What to do
Monitor for anticholinergic symptoms and cognitive effects. Obtain ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Trifluoperazine?
MediHelp rates the interaction as moderate. Solifenacin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine has some anticholinergic activity, so combining it with solifenacin adds to dry mouth, constipation, urinary retention and confusion. Both agents can prolong the QT interval.
How serious is the interaction between Solifenacin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and cognitive effects. Obtain ECG in patients with QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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