Drug interactions
Solifenacin + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Solifenacin and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin and umeclidinium are both antimuscarinics, so combined use can add to dry mouth, constipation, urinary retention, tachycardia and blurred vision. Solifenacin has a dose-related QT effect and vilanterol can add cardiovascular stimulation.
What this interaction means in plain words
Solifenacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, plus possible additive cardiac effects from beta-agonism and QT prolongation.
What to do
Monitor for anticholinergic effects such as urinary retention and constipation, and heart rate and rhythm in patients with cardiac disease or QT risk; consider an alternative to one agent if effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Solifenacin with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Solifenacin and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin and umeclidinium are both antimuscarinics, so combined use can add to dry mouth, constipation, urinary retention, tachycardia and blurred vision. Solifenacin has a dose-related QT effect and vilanterol can add cardiovascular stimulation.
How serious is the interaction between Solifenacin and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention and constipation, and heart rate and rhythm in patients with cardiac disease or QT risk; consider an alternative to one agent if effects are troublesome.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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