Drug interactions
Somapacitan + Thioridazine
Severity: Minor
Somapacitan and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase activity of some cytochrome P450 enzymes, which could lower concentrations of sensitive substrates. The effect on thioridazine is theoretical and thioridazine is chiefly cleared by CYP2D6.
What this interaction means in plain words
Somapacitan and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Somapacitan belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Possible growth hormone-mediated induction of CYP enzymes; not well established for thioridazine.
What to do
No dose change is needed; monitor clinical response to thioridazine when growth hormone therapy is started or changed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Somapacitan with Thioridazine?
MediHelp rates the interaction as minor. Somapacitan and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase activity of some cytochrome P450 enzymes, which could lower concentrations of sensitive substrates. The effect on thioridazine is theoretical and thioridazine is chiefly cleared by CYP2D6.
How serious is the interaction between Somapacitan and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor clinical response to thioridazine when growth hormone therapy is started or changed.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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