Drug interactions
Somatrogon + Tolbutamide
Severity: Moderate
Somatrogon and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs can reduce insulin sensitivity and raise blood glucose. This may weaken the effect of tolbutamide and worsen glycemic control in people with diabetes.
What this interaction means in plain words
Somatrogon and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Somatrogon belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance antagonizes the glucose-lowering effect of tolbutamide.
What to do
Monitor glucose when somatrogon is started or the dose is adjusted. Titrate tolbutamide or other antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Somatrogon with Tolbutamide?
MediHelp rates the interaction as moderate. Somatrogon and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs can reduce insulin sensitivity and raise blood glucose. This may weaken the effect of tolbutamide and worsen glycemic control in people with diabetes.
How serious is the interaction between Somatrogon and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when somatrogon is started or the dose is adjusted. Titrate tolbutamide or other antidiabetic therapy as needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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