Drug interactions
Somatropin + Tacrolimus
Severity: Minor
Somatropin and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP3A4 activity and could lower tacrolimus exposure. Subtherapeutic tacrolimus levels risk graft rejection, so close attention is sensible.
What this interaction means in plain words
Somatropin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Somatropin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible growth hormone-mediated induction of CYP3A4, based on limited data.
What to do
Check tacrolimus trough levels after starting or stopping somatropin and adjust the dose to target range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Somatropin with Tacrolimus?
MediHelp rates the interaction as minor. Somatropin and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP3A4 activity and could lower tacrolimus exposure. Subtherapeutic tacrolimus levels risk graft rejection, so close attention is sensible.
How serious is the interaction between Somatropin and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels after starting or stopping somatropin and adjust the dose to target range.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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