Drug interactions
Somatropin + Tizanidine
Severity: Minor
Somatropin and Tizanidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase the activity of some hepatic cytochrome P450 enzymes, which could lower exposure to drugs cleared by CYP1A2 such as tizanidine. The result may be reduced muscle-relaxant or antispasticity effect, but the clinical significance is uncertain.
What this interaction means in plain words
Somatropin and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Somatropin belongs to Endocrine; Tizanidine belongs to Musculoskeletal.
Why it happens
Possible induction of CYP1A2-mediated metabolism by somatropin, based on limited data with other CYP substrates.
What to do
Monitor for reduced spasticity control when somatropin is started or the dose changed. Titrate tizanidine to clinical response if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Somatropin and Tizanidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Somatropin with Tizanidine?
MediHelp rates the interaction as minor. Somatropin and Tizanidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase the activity of some hepatic cytochrome P450 enzymes, which could lower exposure to drugs cleared by CYP1A2 such as tizanidine. The result may be reduced muscle-relaxant or antispasticity effect, but the clinical significance is uncertain.
How serious is the interaction between Somatropin and Tizanidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced spasticity control when somatropin is started or the dose changed. Titrate tizanidine to clinical response if needed.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
