Drug interactions
Sorafenib + Voxelotor
Severity: Moderate
Sorafenib and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise concentrations of CYP3A4 substrates. Sorafenib is only partially metabolized by CYP3A4, so the increase is likely modest but could heighten toxicity.
What this interaction means in plain words
Sorafenib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, decreasing sorafenib oxidative clearance.
What to do
Monitor for sorafenib adverse effects such as skin toxicity, hypertension and diarrhea and reduce the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Sorafenib with Voxelotor?
MediHelp rates the interaction as moderate. Sorafenib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may raise concentrations of CYP3A4 substrates. Sorafenib is only partially metabolized by CYP3A4, so the increase is likely modest but could heighten toxicity.
How serious is the interaction between Sorafenib and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib adverse effects such as skin toxicity, hypertension and diarrhea and reduce the dose if needed.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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