Drug interactions
Sorafenib + Warfarin
Severity: Moderate
Sorafenib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib increases bleeding risk and has been associated with INR elevations in patients on warfarin. It inhibits CYP2C9 in vitro, though clinical PK effects have been inconsistent.
What this interaction means in plain words
Sorafenib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sorafenib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Possible CYP2C9 inhibition plus additive bleeding risk from VEGFR inhibition.
What to do
Monitor INR regularly during sorafenib therapy and adjust warfarin dose; watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sorafenib and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Sorafenib with Warfarin?
MediHelp rates the interaction as moderate. Sorafenib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib increases bleeding risk and has been associated with INR elevations in patients on warfarin. It inhibits CYP2C9 in vitro, though clinical PK effects have been inconsistent.
How serious is the interaction between Sorafenib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR regularly during sorafenib therapy and adjust warfarin dose; watch for bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
