Drug interactions
Sotorasib + Ticagrelor
Severity: Moderate
Sotorasib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak P-glycoprotein inhibitor and can modestly increase exposure to P-gp substrates such as ticagrelor. This could slightly increase the bleeding tendency, though the effect is likely small. The legacy direction (decrease) is not supported by the mechanism.
What this interaction means in plain words
Sotorasib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Sotorasib inhibits P-glycoprotein, which may reduce efflux of ticagrelor and increase its exposure.
What to do
Monitor for bleeding and bruising when starting sotorasib in a patient taking ticagrelor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Ticagrelor?
MediHelp rates the interaction as moderate. Sotorasib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak P-glycoprotein inhibitor and can modestly increase exposure to P-gp substrates such as ticagrelor. This could slightly increase the bleeding tendency, though the effect is likely small. The legacy direction (decrease) is not supported by the mechanism.
How serious is the interaction between Sotorasib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising when starting sotorasib in a patient taking ticagrelor.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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