Drug interactions
Sotorasib + Topotecan
Severity: Moderate
Sotorasib and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor and would be expected to increase, rather than decrease, exposure to P-gp substrates such as topotecan. This could increase topotecan toxicity, particularly myelosuppression.
What this interaction means in plain words
Sotorasib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Sotorasib inhibits intestinal and cellular P-gp efflux of topotecan, predicted to raise its systemic exposure.
What to do
Avoid oral topotecan with sotorasib where possible; with IV topotecan, monitor blood counts and adjust the dose for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Topotecan?
MediHelp rates the interaction as moderate. Sotorasib and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inhibitor and would be expected to increase, rather than decrease, exposure to P-gp substrates such as topotecan. This could increase topotecan toxicity, particularly myelosuppression.
How serious is the interaction between Sotorasib and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral topotecan with sotorasib where possible; with IV topotecan, monitor blood counts and adjust the dose for toxicity.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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