Drug interactions
Sotorasib + Verapamil
Severity: Moderate
Sotorasib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a weak inducer of CYP3A4 and an inhibitor of P-gp, and verapamil is a substrate of both. Sotorasib may increase rather than decrease verapamil levels through P-gp inhibition, though the effect of CYP3A4 induction may partly offset this, so the net effect is uncertain.
What this interaction means in plain words
Sotorasib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Sotorasib inhibits P-gp and weakly induces CYP3A4, so its net effect on verapamil exposure is unpredictable.
What to do
Monitor heart rate, blood pressure and ECG when starting or stopping sotorasib in patients on verapamil. Adjust the verapamil dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Verapamil?
MediHelp rates the interaction as moderate. Sotorasib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a weak inducer of CYP3A4 and an inhibitor of P-gp, and verapamil is a substrate of both. Sotorasib may increase rather than decrease verapamil levels through P-gp inhibition, though the effect of CYP3A4 induction may partly offset this, so the net effect is uncertain.
How serious is the interaction between Sotorasib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when starting or stopping sotorasib in patients on verapamil. Adjust the verapamil dose according to response.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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