Drug interactions
Sotorasib + Vinblastine
Severity: Moderate
Sotorasib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inhibitor in vitro, which could increase vinblastine exposure, though the legacy direction of effect appears incorrect. Higher vinblastine levels may increase myelosuppression and neurotoxicity.
What this interaction means in plain words
Sotorasib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sotorasib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Sotorasib may inhibit P-gp efflux of vinblastine, increasing its exposure.
What to do
Monitor blood counts and neurotoxicity. Consider a vinblastine dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Sotorasib with Vinblastine?
MediHelp rates the interaction as moderate. Sotorasib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inhibitor in vitro, which could increase vinblastine exposure, though the legacy direction of effect appears incorrect. Higher vinblastine levels may increase myelosuppression and neurotoxicity.
How serious is the interaction between Sotorasib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity. Consider a vinblastine dose reduction if toxicity develops.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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