Drug interactions
Sparsentan + Spironolactone
Severity: Major
Sparsentan and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan blocks the angiotensin II type 1 receptor, reducing aldosterone effects, and spironolactone also antagonizes aldosterone. The combination can produce hyperkalemia, and sparsentan labeling advises caution with potassium-sparing diuretics.
What this interaction means in plain words
Sparsentan and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sparsentan belongs to Genitourinary; Spironolactone belongs to Cardiovascular.
Why it happens
Additive reduction of aldosterone-mediated renal potassium excretion via AT1 blockade and mineralocorticoid receptor antagonism.
What to do
Avoid concurrent use where possible; if needed, monitor serum potassium and renal function frequently and adjust therapy for rising potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Spironolactone?
MediHelp rates the interaction as major. Sparsentan and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan blocks the angiotensin II type 1 receptor, reducing aldosterone effects, and spironolactone also antagonizes aldosterone. The combination can produce hyperkalemia, and sparsentan labeling advises caution with potassium-sparing diuretics.
How serious is the interaction between Sparsentan and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if needed, monitor serum potassium and renal function frequently and adjust therapy for rising potassium.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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