Drug interactions
Sparsentan + Tamoxifen
Severity: Moderate
Sparsentan and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan can induce CYP2C9 and may lower exposure to tamoxifen's metabolites formed by this pathway. The clinical effect on tamoxifen efficacy is not well characterized.
What this interaction means in plain words
Sparsentan and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sparsentan belongs to Genitourinary; Tamoxifen belongs to Endocrine.
Why it happens
Sparsentan induces CYP2C9, potentially increasing tamoxifen clearance.
What to do
Monitor for reduced tamoxifen response if the drugs are combined. Reassess the need for both agents and the endocrine therapy plan periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Tamoxifen?
MediHelp rates the interaction as moderate. Sparsentan and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan can induce CYP2C9 and may lower exposure to tamoxifen's metabolites formed by this pathway. The clinical effect on tamoxifen efficacy is not well characterized.
How serious is the interaction between Sparsentan and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tamoxifen response if the drugs are combined. Reassess the need for both agents and the endocrine therapy plan periodically.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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