Drug interactions
Sparsentan + Tolmetin
Severity: Major
Sparsentan and Tolmetin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan affects renal hemodynamics through endothelin and angiotensin receptor blockade, and NSAIDs can further reduce renal perfusion. Renal function may deteriorate and fluid retention or hyperkalemia may occur.
What this interaction means in plain words
Sparsentan and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sparsentan belongs to Genitourinary; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins adds to efferent arteriolar dilation from angiotensin receptor blockade, reducing glomerular filtration.
What to do
Avoid NSAIDs where possible and use alternative analgesia. If concurrent use is necessary, monitor serum creatinine, potassium and fluid status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Sparsentan with Tolmetin?
MediHelp rates the interaction as major. Sparsentan and Tolmetin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan affects renal hemodynamics through endothelin and angiotensin receptor blockade, and NSAIDs can further reduce renal perfusion. Renal function may deteriorate and fluid retention or hyperkalemia may occur.
How serious is the interaction between Sparsentan and Tolmetin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible and use alternative analgesia. If concurrent use is necessary, monitor serum creatinine, potassium and fluid status.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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