Drug interactions
Spironolactone + Treprostinil
Severity: Minor
Spironolactone and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator that lowers blood pressure, and spironolactone also has blood pressure lowering effects. Taken together they may cause additive hypotension. The effect is usually modest and manageable.
What this interaction means in plain words
Spironolactone and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Spironolactone belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and diuretic blood pressure lowering effects.
What to do
Monitor blood pressure and for symptoms of hypotension when starting or titrating either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Spironolactone with Treprostinil?
MediHelp rates the interaction as minor. Spironolactone and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a vasodilator that lowers blood pressure, and spironolactone also has blood pressure lowering effects. Taken together they may cause additive hypotension. The effect is usually modest and manageable.
How serious is the interaction between Spironolactone and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for symptoms of hypotension when starting or titrating either drug. Reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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