Drug interactions
Streptomycin + Sulindac
Severity: Minor
Streptomycin and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, raising serum levels, mainly documented in premature neonates treated with indomethacin. Sulindac has relatively little renal prostaglandin effect, and the interaction is poorly documented for adults.
What this interaction means in plain words
Streptomycin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Streptomycin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Reduced renal prostaglandin-dependent blood flow and glomerular filtration lowers aminoglycoside clearance.
What to do
No routine action is needed in adults with normal renal function. Monitor renal function and streptomycin levels in neonates or patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Streptomycin with Sulindac?
MediHelp rates the interaction as minor. Streptomycin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal clearance of aminoglycosides, raising serum levels, mainly documented in premature neonates treated with indomethacin. Sulindac has relatively little renal prostaglandin effect, and the interaction is poorly documented for adults.
How serious is the interaction between Streptomycin and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed in adults with normal renal function. Monitor renal function and streptomycin levels in neonates or patients with renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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