Drug interactions
Streptomycin + Tolfenamic acid
Severity: Moderate
Streptomycin and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can lower renal perfusion and glomerular filtration, which may slow aminoglycoside elimination and raise levels. This increases the risk of nephrotoxicity and ototoxicity, especially in neonates, the elderly or dehydrated patients.
What this interaction means in plain words
Streptomycin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Streptomycin belongs to Anti Bacterial; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular filtration and aminoglycoside clearance.
What to do
Monitor serum creatinine and streptomycin levels and adjust the dose to renal function. Use an alternative analgesic if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Streptomycin with Tolfenamic acid?
MediHelp rates the interaction as moderate. Streptomycin and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can lower renal perfusion and glomerular filtration, which may slow aminoglycoside elimination and raise levels. This increases the risk of nephrotoxicity and ototoxicity, especially in neonates, the elderly or dehydrated patients.
How serious is the interaction between Streptomycin and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels and adjust the dose to renal function. Use an alternative analgesic if renal function is impaired.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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