Drug interactions
Streptomycin + Voclosporin
Severity: Major
Streptomycin and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can reduce kidney function, and streptomycin is nephrotoxic. Combined use may increase the risk of acute kidney injury and secondarily raise streptomycin exposure and ototoxicity.
What this interaction means in plain words
Streptomycin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Streptomycin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity from calcineurin inhibition-related renal vasoconstriction and aminoglycoside tubular injury.
What to do
Avoid the combination if possible. If necessary, monitor eGFR and serum creatinine frequently, adjust streptomycin dosing to renal function, and follow voclosporin dose-reduction guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Streptomycin
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Streptomycin with Voclosporin?
MediHelp rates the interaction as major. Streptomycin and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can reduce kidney function, and streptomycin is nephrotoxic. Combined use may increase the risk of acute kidney injury and secondarily raise streptomycin exposure and ototoxicity.
How serious is the interaction between Streptomycin and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor eGFR and serum creatinine frequently, adjust streptomycin dosing to renal function, and follow voclosporin dose-reduction guidance.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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