Drug interactions
Succinylcholine + Sufentanil sl
Severity: Moderate
Succinylcholine and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil is a potent opioid causing respiratory depression and sedation, and succinylcholine paralyzes respiratory muscles. Together they raise the risk of hypoventilation, hypotension and deep sedation. Use is acceptable only where ventilation can be controlled.
What this interaction means in plain words
Succinylcholine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects: opioid-induced central respiratory depression combined with neuromuscular paralysis.
What to do
Give succinylcholine only with airway and ventilatory support available, and reduce opioid or sedative doses as needed. Monitor respiratory rate, oxygen saturation and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Succinylcholine with Sufentanil sl?
MediHelp rates the interaction as moderate. Succinylcholine and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sublingual sufentanil is a potent opioid causing respiratory depression and sedation, and succinylcholine paralyzes respiratory muscles. Together they raise the risk of hypoventilation, hypotension and deep sedation. Use is acceptable only where ventilation can be controlled.
How serious is the interaction between Succinylcholine and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give succinylcholine only with airway and ventilatory support available, and reduce opioid or sedative doses as needed. Monitor respiratory rate, oxygen saturation and blood pressure.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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