Drug interactions
Sufentanil sl + Voriconazole
Severity: Major
Sufentanil sl and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can substantially raise sufentanil concentrations from the sublingual tablet. This may cause prolonged or excessive opioid effects including potentially fatal respiratory depression and sedation.
What this interaction means in plain words
Sufentanil sl and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of sufentanil.
What to do
Monitor closely for respiratory depression and sedation, particularly when starting or stopping voriconazole. Consider an opioid not dependent on CYP3A4 or reduce dosing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Sufentanil sl with Voriconazole?
MediHelp rates the interaction as major. Sufentanil sl and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole can substantially raise sufentanil concentrations from the sublingual tablet. This may cause prolonged or excessive opioid effects including potentially fatal respiratory depression and sedation.
How serious is the interaction between Sufentanil sl and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for respiratory depression and sedation, particularly when starting or stopping voriconazole. Consider an opioid not dependent on CYP3A4 or reduce dosing.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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