Drug interactions
Sulbactam / durlobactam + Tacrolimus
Severity: Minor
Sulbactam / durlobactam and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulbactam is eliminated renally through active tubular secretion. Tacrolimus is not a recognized inhibitor of this pathway, so a meaningful interaction is unlikely, though both can affect renal function.
What this interaction means in plain words
Sulbactam / durlobactam and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of renal tubular secretion of sulbactam is theoretical and not established for tacrolimus.
What to do
No dose change is needed. Monitor renal function and tacrolimus troughs during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Sulbactam / durlobactam with Tacrolimus?
MediHelp rates the interaction as minor. Sulbactam / durlobactam and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulbactam is eliminated renally through active tubular secretion. Tacrolimus is not a recognized inhibitor of this pathway, so a meaningful interaction is unlikely, though both can affect renal function.
How serious is the interaction between Sulbactam / durlobactam and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor renal function and tacrolimus troughs during treatment.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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