Drug interactions
Sulindac + Tobramycin
Severity: Minor
Sulindac and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce renal elimination of aminoglycosides, increasing exposure and nephrotoxicity or ototoxicity risk. Evidence comes mainly from neonates given indomethacin, and sulindac is considered less renally active.
What this interaction means in plain words
Sulindac and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sulindac belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
Inhibition of renal prostaglandin synthesis decreases glomerular filtration and aminoglycoside clearance.
What to do
Monitor serum creatinine and tobramycin trough levels, especially in neonates, older adults, or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Sulindac with Tobramycin?
MediHelp rates the interaction as minor. Sulindac and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may reduce renal elimination of aminoglycosides, increasing exposure and nephrotoxicity or ototoxicity risk. Evidence comes mainly from neonates given indomethacin, and sulindac is considered less renally active.
How serious is the interaction between Sulindac and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, especially in neonates, older adults, or those with renal impairment.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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