Drug interactions
Sulindac + Tolvaptan
Severity: Moderate
Sulindac and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac can reduce renal function and potassium excretion, while tolvaptan causes aquaresis and volume shifts. Together they may add to the risk of renal impairment and electrolyte disturbance, although the interaction is not well characterized.
What this interaction means in plain words
Sulindac and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
NSAID inhibition of renal prostaglandins can lower renal perfusion and potassium handling, whereas tolvaptan-induced volume depletion increases renal vulnerability; a direct interaction is not well established.
What to do
Monitor serum creatinine, sodium and potassium, and volume status when the drugs are used together. Avoid prolonged NSAID use if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Sulindac with Tolvaptan?
MediHelp rates the interaction as moderate. Sulindac and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulindac can reduce renal function and potassium excretion, while tolvaptan causes aquaresis and volume shifts. Together they may add to the risk of renal impairment and electrolyte disturbance, although the interaction is not well characterized.
How serious is the interaction between Sulindac and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, sodium and potassium, and volume status when the drugs are used together. Avoid prolonged NSAID use if renal function declines.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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