Drug interactions
Sulindac + Triamcinolone
Severity: Moderate
Sulindac and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a corticosteroid with an NSAID increases the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is higher in older patients, with high doses and with prolonged therapy.
What this interaction means in plain words
Sulindac and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sulindac belongs to Musculoskeletal; Triamcinolone belongs to Endocrine.
Why it happens
Additive gastrointestinal injury: NSAID inhibition of protective prostaglandins plus corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor in at-risk patients. Counsel patients to report melena or severe abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Sulindac with Triamcinolone?
MediHelp rates the interaction as moderate. Sulindac and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a corticosteroid with an NSAID increases the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is higher in older patients, with high doses and with prolonged therapy.
How serious is the interaction between Sulindac and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor in at-risk patients. Counsel patients to report melena or severe abdominal pain.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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