Drug interactions
Sulindac + Triamterene
Severity: Major
Sulindac and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a potassium-sparing diuretic and NSAIDs reduce renal prostaglandin synthesis, which can cause hyperkalemia and acute kidney injury. This combination is of particular concern because indomethacin and other NSAIDs have been associated with nephrotoxicity when given with triamterene.
What this interaction means in plain words
Sulindac and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sulindac belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
Reduced renal perfusion and suppressed renin-aldosterone activity from NSAIDs, combined with triamterene blockade of distal sodium channels that limits potassium excretion.
What to do
Avoid the combination if possible. If used, monitor serum potassium and creatinine closely and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Sulindac with Triamterene?
MediHelp rates the interaction as major. Sulindac and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triamterene is a potassium-sparing diuretic and NSAIDs reduce renal prostaglandin synthesis, which can cause hyperkalemia and acute kidney injury. This combination is of particular concern because indomethacin and other NSAIDs have been associated with nephrotoxicity when given with triamterene.
How serious is the interaction between Sulindac and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor serum potassium and creatinine closely and ensure adequate hydration.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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