Drug interactions
Sulindac + Valganciclovir
Severity: Minor
Sulindac and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac and its metabolites may compete with ganciclovir for renal tubular secretion, potentially raising ganciclovir exposure. The clinical significance is uncertain but ganciclovir toxicity includes myelosuppression and renal effects.
What this interaction means in plain words
Sulindac and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sulindac belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition for renal organic anion transporter-mediated tubular secretion.
What to do
Monitor blood counts and renal function during co-therapy, and adjust the valganciclovir dose to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Sulindac with Valganciclovir?
MediHelp rates the interaction as minor. Sulindac and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulindac and its metabolites may compete with ganciclovir for renal tubular secretion, potentially raising ganciclovir exposure. The clinical significance is uncertain but ganciclovir toxicity includes myelosuppression and renal effects.
How serious is the interaction between Sulindac and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function during co-therapy, and adjust the valganciclovir dose to renal function.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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