Drug interactions
Sunitinib + Venetoclax
Severity: Moderate
Sunitinib and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax is a P-gp substrate and sunitinib may inhibit P-gp, potentially raising venetoclax exposure. This could increase neutropenia and tumour lysis risk.
What this interaction means in plain words
Sunitinib and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Venetoclax belongs to Miscellaneous.
Why it happens
Possible P-gp inhibition by sunitinib increases venetoclax exposure.
What to do
Monitor blood counts and tumour lysis parameters. Consider reducing the venetoclax dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Sunitinib with Venetoclax?
MediHelp rates the interaction as moderate. Sunitinib and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax is a P-gp substrate and sunitinib may inhibit P-gp, potentially raising venetoclax exposure. This could increase neutropenia and tumour lysis risk.
How serious is the interaction between Sunitinib and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tumour lysis parameters. Consider reducing the venetoclax dose if toxicity develops.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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