Drug interactions
Sunitinib + Voclosporin
Severity: Moderate
Sunitinib and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both sunitinib and voclosporin have been associated with QT interval prolongation, so using them together may add to the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia or underlying cardiac disease.
What this interaction means in plain words
Sunitinib and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc periodically, and correct potassium and magnesium before and during therapy. Reassess the combination if QTc rises markedly or symptoms such as syncope or palpitations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Sunitinib with Voclosporin?
MediHelp rates the interaction as moderate. Sunitinib and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both sunitinib and voclosporin have been associated with QT interval prolongation, so using them together may add to the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia or underlying cardiac disease.
How serious is the interaction between Sunitinib and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, and correct potassium and magnesium before and during therapy. Reassess the combination if QTc rises markedly or symptoms such as syncope or palpitations occur.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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