Drug interactions
Sunitinib + Zafirlukast
Severity: Moderate
Sunitinib and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is a CYP3A4 substrate, and zafirlukast may increase exposure to it and its active metabolite. This may increase toxicities such as hepatotoxicity, hypertension, myelosuppression and QT prolongation.
What this interaction means in plain words
Sunitinib and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sunitinib belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated sunitinib metabolism by zafirlukast.
What to do
Monitor liver function, blood pressure and blood counts. Reduce the sunitinib dose if toxicity develops, or choose an alternative to zafirlukast.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Sunitinib with Zafirlukast?
MediHelp rates the interaction as moderate. Sunitinib and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib is a CYP3A4 substrate, and zafirlukast may increase exposure to it and its active metabolite. This may increase toxicities such as hepatotoxicity, hypertension, myelosuppression and QT prolongation.
How serious is the interaction between Sunitinib and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function, blood pressure and blood counts. Reduce the sunitinib dose if toxicity develops, or choose an alternative to zafirlukast.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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