Drug interactions
Suvorexant + Ticagrelor
Severity: Minor
Suvorexant and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor weakly inhibits CYP3A4 and may modestly increase suvorexant levels, leading to more daytime somnolence.
What this interaction means in plain words
Suvorexant and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Suvorexant belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Ticagrelor weakly inhibits CYP3A4, reducing suvorexant clearance.
What to do
Start suvorexant at the lowest dose and counsel about next-day drowsiness and driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Suvorexant with Ticagrelor?
MediHelp rates the interaction as minor. Suvorexant and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor weakly inhibits CYP3A4 and may modestly increase suvorexant levels, leading to more daytime somnolence.
How serious is the interaction between Suvorexant and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at the lowest dose and counsel about next-day drowsiness and driving.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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