Drug interactions
Tacrolimus + Telotristat ethyl
Severity: Moderate
Tacrolimus and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl may induce CYP3A4 and lower tacrolimus concentrations. Reduced exposure may lead to loss of immunosuppression and a risk of graft rejection.
What this interaction means in plain words
Tacrolimus and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by telotristat increases tacrolimus metabolism.
What to do
Monitor tacrolimus trough concentrations after starting or stopping telotristat and increase the tacrolimus dose if levels fall below target.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Telotristat ethyl?
MediHelp rates the interaction as moderate. Tacrolimus and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat ethyl may induce CYP3A4 and lower tacrolimus concentrations. Reduced exposure may lead to loss of immunosuppression and a risk of graft rejection.
How serious is the interaction between Tacrolimus and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations after starting or stopping telotristat and increase the tacrolimus dose if levels fall below target.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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