Drug interactions
Tacrolimus + Teniposide
Severity: Moderate
Tacrolimus and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus inhibits P-glycoprotein and could increase teniposide exposure. This may heighten myelosuppression and other teniposide toxicity, though clinical data are limited.
What this interaction means in plain words
Tacrolimus and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tacrolimus inhibits P-glycoprotein efflux of teniposide, potentially increasing its exposure.
What to do
Monitor blood counts closely and consider teniposide dose reduction if myelosuppression or toxicity is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Teniposide?
MediHelp rates the interaction as moderate. Tacrolimus and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus inhibits P-glycoprotein and could increase teniposide exposure. This may heighten myelosuppression and other teniposide toxicity, though clinical data are limited.
How serious is the interaction between Tacrolimus and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider teniposide dose reduction if myelosuppression or toxicity is excessive.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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