Drug interactions
Tacrolimus + Tenofovir df
Severity: Moderate
Tacrolimus and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and concurrent use may increase the risk of renal impairment. Tenofovir can cause proximal tubular toxicity, while tacrolimus reduces renal blood flow.
What this interaction means in plain words
Tacrolimus and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity through different mechanisms: tubular toxicity from tenofovir and vasoconstriction from tacrolimus.
What to do
Monitor serum creatinine, phosphate and tacrolimus trough levels regularly. Consider tenofovir alafenamide or an alternative if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Tenofovir df?
MediHelp rates the interaction as moderate. Tacrolimus and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and concurrent use may increase the risk of renal impairment. Tenofovir can cause proximal tubular toxicity, while tacrolimus reduces renal blood flow.
How serious is the interaction between Tacrolimus and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and tacrolimus trough levels regularly. Consider tenofovir alafenamide or an alternative if renal function declines.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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