Drug interactions
Tacrolimus + Testosterone buccal system
Severity: Minor
Tacrolimus and Testosterone buccal system: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone may modestly increase tacrolimus levels, though effects at replacement doses are likely small. Tacrolimus toxicity is the concern if levels rise.
What this interaction means in plain words
Tacrolimus and Testosterone buccal system have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of tacrolimus metabolism; the mechanism is not firmly established.
What to do
Check tacrolimus trough levels after starting or stopping testosterone and adjust the dose if levels shift.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Tacrolimus with Testosterone buccal system?
MediHelp rates the interaction as minor. Tacrolimus and Testosterone buccal system have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone may modestly increase tacrolimus levels, though effects at replacement doses are likely small. Tacrolimus toxicity is the concern if levels rise.
How serious is the interaction between Tacrolimus and Testosterone buccal system?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels after starting or stopping testosterone and adjust the dose if levels shift.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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